The airway microbiome in patients with severe asthma: Associations with disease features and severity
Huang YJ, Nariya S, Harris J, Lynch SV, Choy D, Arron JR, Boushey HA. J Allergy Clin Immunol 2015 Oct;136(4):874-84.
Background:Asthma is heterogeneous, and airway dysbiosis is associated with clinical features in patients with mild-to-moderate asthma. Whether similar relationships exist among patients with severe asthma is unknown.
The Microbiome in Allergic Disease: Current Understanding and Future Opportunities – 2017 PRACTALL Document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology
Background:There is increasing evidence that resident microbial communities in the human gastrointestinal tract, airway, and skin contribute to health and disease. This complex relationship between the microbiota and the human host could lend itself to manipulation to benefit the host
Features of the bronchial bacterial microbiome associated with atopy, asthma and responsiveness to inhaled corticosteroid treatment
Durack J, Lynch SV, Nariya S, Bhakta NR, Beigelman A, Castro M, Israel E, Kraft M, Martin RJ, Mauger D, Rosenberg S, Sharp-King T, White SR, Woodruff PG, Avila PC, Denlinger LC, Holguin F, Lazarus SC, Lugogo N, Moore WC, Peters SP, Que L, Smith LJ, Sorkness CA, Wechsler M, Wenzel SE, Boushey HA, and Huang YJ. . J Allergy Clin Immunol 2017 Jul,140(1):63-75. [Epub 2016 Nov 10.] PMC- in progress
Background: Compositional differences in the bronchial bacterial microbiota have been associated with asthma, but it remains unclear whether the findings are attributable to asthma, to aeroallergen sensitization, or to inhaled corticosteroid treatment. Read More at PMID 27838347
Incorporating the airway microbiome into asthma phenotyping - moving towards personalized medicine for noneosinophilic asthma
Durack J, Boushey HA, Huang YJ. J Allergy Clin Immunol 2017 Jun 13. pii: S0091-6749(17)30931-4
Background: Asthma is highly heterogeneous in severity and in patterns of airway immune responses.This heterogeneity, which was expressed as differences in asthma phenotypes, challenges the effectiveness of uniform management strategies.